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Investigators study changes in myoblast fusion and the increase in mitochondrial density within newly formed fibers

The most recent diagnostic guidelines propose three main criteria for diagnosing MCAS: Clinical symptoms consistent with mast cell mediator release affecting multiple organ systems Evidence of mast cell mediator release during symptomatic periods (through laboratory testing) Response to medications that block or reduce mast cell mediator production or effects For many patients, the road to diagnosis is long and frustrating

Mechanistically, capsaicin activates endothelial TRPV4 and intermediate-conductance Ca 2+ -activated potassium channels, which induce membrane hyperpolarization and promote vasorelaxation (133)

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doi: 10.1038/nature01868 63 CrabbeJ